Considering the difficulty of modeling the interaction between labels and solidification of global label relationship in multi-label image classification tasks， a new Multiple-Label image classification method based on Global and Local Label Relationship （ML-GLLR） was proposed by combining self-attention mechanism and Knowledge Distillation （KD） method. Firstly， Convolutional Neural Network （CNN）， semantic module and Dual Layer Self-Attention （DLSA） module were used by the Local Label Relationship （LLR） model to model local label relationship. Then， the KD method was used to make LLR learn global label relationship. The experimental results on the public datasets of MicroSoft Common Objects in COntext （MSCOCO） 2014 and PASCAL VOC challenge 2007 （VOC2007） show that， LLR improves the mean Average Precision （mAP） by 0.8 percentage points and 0.6 percentage points compared with Multiple Label classification based on Graph Convolutional Network （ML-GCN） respectively， and the proposed ML-GLLR increases the mAP by 0.2 percentage points and 1.3 percentage points compared with LLR. Experimental results show that， the proposed ML-GLLR can not only model the interaction between labels， but also avoid the problem of global label relationship solidification.